Vitamin B3-Based Biologically Active Compounds as Inhibitors of Human Cholinesterases

Vitamin B3-Based Biologically Active Compounds as Inhibitors of Human Cholinesterases

We evaluated the potential of nine vitamin B3 scaffold-based derivatives as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors, as a starting point for the development of novel drugs for treating disorders with cholinergic neurotransmission-linked pathology. As the results indic...

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Bibliographic Details
Main Authors: Antonio Zandona, Gabriela Lihtar, Nikola Maraković, Katarina Miš, Valentina Bušić, Dajana Gašo-Sokač, Sergej Pirkmajer, Maja Katalinić
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
AChE
BChE
neurodegenerative
Alzheimer’s
nicotinamide
cytotoxicity
Online Access:https://www.mdpi.com/1422-0067/21/21/8088

Internet

https://www.mdpi.com/1422-0067/21/21/8088

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