Systemic lupus erythematosus: molecular mimicry between anti-dsDNA CDR3 idiotype, microbial and self peptides as antigens for Th cells

Systemic lupus erythematosus: molecular mimicry between anti-dsDNA CDR3 idiotype, microbial and self peptides as antigens for Th cells

Systemic lupus erythematosus (SLE) is marked by a T helper (Th) cell dependent B cell hyperresponsiveness, with frequent germinal center reactions, and gammaglobulinemia. A hallmark of SLE is the finding of IgG autoantibodies specific for dsDNA. The specificity of the Th cells that drive the expansi...

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Bibliographic Details
Main Authors: Kristin eAas-Hanssen, Keith M Thompson, Bjarne eBogen, Ludvig A Munthe
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-07-01
Series:Frontiers in Immunology
Subjects:
Molecular Mimicry
B cells
Th cells
systemic lupus erythematosus
Idiotypes
B cell receptor (BCR)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00382/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00382/full

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