Insights into the Mechanism and Catalysis of Peptide Thioester Synthesis by Alkylselenols Provide a New Tool for Chemical Protein Synthesis

Insights into the Mechanism and Catalysis of Peptide Thioester Synthesis by Alkylselenols Provide a New Tool for Chemical Protein Synthesis

While thiol-based catalysts are widely employed for chemical protein synthesis relying on peptide thioester chemistry, this is less true for selenol-based catalysts whose development is in its infancy. In this study, we compared different selenols derived from the selenocysteamine scaffold for their...

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Bibliographic Details
Main Authors: Florent Kerdraon, Gemma Bogard, Benoît Snella, Hervé Drobecq, Muriel Pichavant, Vangelis Agouridas, Oleg Melnyk
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Molecules
Subjects:
peptide thioester
alkylselenol
catalysis
chemical protein synthesis
Online Access:https://www.mdpi.com/1420-3049/26/5/1386

Internet

https://www.mdpi.com/1420-3049/26/5/1386

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