Amyloid Beta Oligomers Target to Extracellular and Intracellular Neuronal Synaptic Proteins in Alzheimer's Disease

Amyloid Beta Oligomers Target to Extracellular and Intracellular Neuronal Synaptic Proteins in Alzheimer's Disease

Introduction: β-Amyloid protein (Aβ) putatively plays a seminal role in synaptic loss in Alzheimer's disease (AD). While there is no consensus regarding the synaptic-relevant species of Aβ, it is known that Aβ oligomers (AβOs) are noticeably increased in the early stages of AD, localizing at or...

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Bibliographic Details
Main Authors: Yu Ding, Jiahui Zhao, Xunle Zhang, Shanshan Wang, Kirsten L. Viola, Frances E. Chow, Yang Zhang, Carol Lippa, William L. Klein, Yuesong Gong
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Neurology
Subjects:
Alzheimer's disease
synapse
postsynaptic density
soluble Aβ oligomers
α3-Na/K-ATPase
synGap
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.01140/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2019.01140/full

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