Abnormal gait, reduced locomotor activity and impaired motor coordination in Dgcr2-deficient mice

Abnormal gait, reduced locomotor activity and impaired motor coordination in Dgcr2-deficient mice

It has been suggested that the DGCR2 gene plays a role in the pathogenesis of 22q11.2 deletion syndrome. To analyze its function, we used our Dgcr2-knock-out/EGFP-knock-in mice (Dgcr2-KO mice). At 20-26 weeks of age, approximately 20% of Dgcr2-KO mice showed gait abnormalities with trembling and dif...

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Bibliographic Details
Main Authors: Shin-ichiro Mugikura, Akira Katoh, Satoshi Watanabe, Minoru Kimura, Kagemasa Kajiwara
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Biochemistry and Biophysics Reports
Subjects:
Dgcr2 gene
knock-out mice
22q11.2 deletion syndrome
Motor coordination
Abnormal gait
Purkinje cell
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580815001351

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http://www.sciencedirect.com/science/article/pii/S2405580815001351

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