Naïve Regulatory T Cell Subset Is Altered in X-Linked Agammaglobulinemia

Naïve Regulatory T Cell Subset Is Altered in X-Linked Agammaglobulinemia

The interplay between T- and B-cell compartments during naïve, effector and memory T cell maturation is critical for a balanced immune response. Primary B-cell immunodeficiency arising from X-linked agammaglobulinemia (XLA) offers a model to explore B cell impact on T cell subsets, starting from the...

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Main Authors: Pavel V. Shelyakin, Ksenia R. Lupyr, Evgeny S. Egorov, Ilya A. Kofiadi, Dmitriy B. Staroverov, Sofya A. Kasatskaya, Valeriia V. Kriukova, Irina A. Shagina, Ekaterina M. Merzlyak, Tatiana O. Nakonechnaya, Elena A. Latysheva, Irina A. Manto, Musa R. Khaitov, Sergey A. Lukyanov, Dmitriy M. Chudakov, Olga V. Britanova
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
X-linked agammaglobulinemia (XLA)
TCR repertoire
T cell gene expression
naïve regulatory T cells
CDR3β features
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.697307/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.697307/full

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