Drug Repurposing for Duchenne Muscular Dystrophy: The Monoamine Oxidase B Inhibitor Safinamide Ameliorates the Pathological Phenotype in mdx Mice and in Myogenic Cultures From DMD Patients

Drug Repurposing for Duchenne Muscular Dystrophy: The Monoamine Oxidase B Inhibitor Safinamide Ameliorates the Pathological Phenotype in mdx Mice and in Myogenic Cultures From DMD Patients

Oxidative stress and mitochondrial dysfunction play a crucial role in the pathophysiology of muscular dystrophies. We previously reported that the mitochondrial enzyme monoamine oxidase (MAO) is a relevant source of reactive oxygen species (ROS) not only in murine models of muscular dystrophy, in wh...

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Bibliographic Details
Main Authors: Libero Vitiello, Manuela Marabita, Elisa Sorato, Leonardo Nogara, Giada Forestan, Vincent Mouly, Leonardo Salviati, Manuel Acosta, Bert Blaauw, Marcella Canton
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Physiology
Subjects:
muscular dystrophy
mitochondrial ROS
monoamine oxidase
oxidative stress
safinamide
DMD
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01087/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.01087/full

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