Spatial epigenetic control of mono- and bistable gene expression.

Bistability in signaling networks is frequently employed to promote stochastic switch-like transitions between cellular differentiation states. Differentiation can also be triggered by antagonism of activators and repressors mediated by epigenetic processes that constitute regulatory circuits anchor...

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Bibliographic Details
Main Authors: János Z Kelemen, Prasuna Ratna, Simone Scherrer, Attila Becskei
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-03-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC2838748?pdf=render