Dulaglutide Modulates the Development of Tissue-Infiltrating Th1/Th17 Cells and the Pathogenicity of Encephalitogenic Th1 Cells in the Central Nervous System

Dulaglutide Modulates the Development of Tissue-Infiltrating Th1/Th17 Cells and the Pathogenicity of Encephalitogenic Th1 Cells in the Central Nervous System

GLP-1 (glucagon-like peptide-1) has been reported to play a vital role in neuroprotection. Experimental autoimmune encephalomyelitis (EAE) is a well-established animal model widely used to study human multiple sclerosis, a chronic demyelination disease in the central nervous system (CNS). Recently,...

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Bibliographic Details
Main Authors: Hsin-Ying Clair Chiou, Ming-Wei Lin, Pi-Jung Hsiao, Chun-Lin Chen, Shiang Chiao, Ting-Yi Lin, Yi-Chen Chen, Deng-Chyang Wu, Ming-Hong Lin
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
Experimental autoimmune encephalomyelitis
dulaglutide
GLP-1 RA
autoreactive T cells
Th1
Th17
encephalitogenicity
dendritic cells (DCs)
macrophages
multiple sclerosis
central nervous system
Online Access:https://www.mdpi.com/1422-0067/20/7/1584

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https://www.mdpi.com/1422-0067/20/7/1584

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