IL-33 is produced by colon fibroblasts and differentially regulated in acute and chronic murine colitis

Abstract IL-33 is upregulated in ulcerative colitis and has a protective role in chemically-induced acute murine colitis. We aimed to determine whether IL-33 influences Il10 −/− chronic colitis and its cellular source in health and during colitis. Il10 −/− Il33 −/− and Il10 −/− Il33 +/+ littermates...

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Bibliographic Details
Main Authors: Amanda Waddell, Jefferson E. Vallance, Sejal Fox, Michael J. Rosen
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-89119-1