Optimal Classes of Chemotherapeutic Agents Sensitized by Specific Small-Molecule Inhibitors of Akt In Vitro and In Vivo

Optimal Classes of Chemotherapeutic Agents Sensitized by Specific Small-Molecule Inhibitors of Akt In Vitro and In Vivo

Akt is a serine/threonine kinase that transduces survival signals from survival/growth factors. Deregulation and signal imbalance in cancer cells make them prone to apoptosis. Upregulation or activation of Akt to aid the survival of cancer cells is a common theme in human malignancies. We have deve...

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Bibliographic Details
Main Authors: Yan Shi, Xuesong Liu, Edward K. Han, Ran Guan, Alexander R. Shoemaker, Anatol Oleksijew, Keith W. Woods, John P. Fisher, Vered Klinghofer, Loren Lasko, Thomas McGonigal, Qun Li, Saul H. Rosenberg, Vincent L. Giranda, Yan Luo
Format: Article
Language:English
Published: Elsevier 2005-11-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Akt
inhibitors
chemosensitization
apoptosis
synergy
Online Access:http://www.sciencedirect.com/science/article/pii/S147655860580034X

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http://www.sciencedirect.com/science/article/pii/S147655860580034X

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