Systemic Lipopolysaccharide-Induced Pain Sensitivity and Spinal Inflammation Were Reduced by Minocycline in Neonatal Rats

Systemic Lipopolysaccharide-Induced Pain Sensitivity and Spinal Inflammation Were Reduced by Minocycline in Neonatal Rats

In this study, we investigated the effects of minocycline, a putative suppressor of microglial activation, on systemic lipopolysaccharide (LPS)-induced spinal cord inflammation, allodynia, and hyperalgesia in neonatal rats. Intraperitoneal (i.p.) injection of LPS (2 mg/kg) or sterile saline was perf...

Full description

Bibliographic Details
Main Authors: Cheng-Ta Hsieh, Yih-Jing Lee, Xiaoli Dai, Norma Beatriz Ojeda, Hyun Joon Lee, Lu-Tai Tien, Lir-Wan Fan
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:International Journal of Molecular Sciences
Subjects:
minocycline
lipopolysaccharide
hyperalgesia
allodynia
spinal cord inflammation
Online Access:http://www.mdpi.com/1422-0067/19/10/2947

Internet

http://www.mdpi.com/1422-0067/19/10/2947

Similar Items