A vaccine with Aβ oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer’s disease

A vaccine with Aβ oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer’s disease

Abstract Background β-Amyloid peptide (Aβ) oligomers are initial factors used to induce Alzheimer’s disease (AD) development, and Aβ monomers have normal physiological function. The antibodies or vaccines against Aβ monomers have serious problems, such as side effects and low curative effects. There...

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Bibliographic Details
Main Authors: Shao-wei Wang, Dong-qun Liu, Ling-xiao Zhang, Mei Ji, Yang-xin Zhang, Quan-xiu Dong, Shu-ying Liu, Xi-xiu Xie, Rui-tian Liu
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
β-amyloid oligomer
Mimotope
Saccharomyces cerevisiae
Vaccine
Online Access:http://link.springer.com/article/10.1186/s13195-017-0267-5

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http://link.springer.com/article/10.1186/s13195-017-0267-5

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