Sirtuin 1 Regulates Mitochondrial Biogenesis and Provides an Endogenous Neuroprotective Mechanism Against Seizure-Induced Neuronal Cell Death in the Hippocampus Following Status Epilepticus

Sirtuin 1 Regulates Mitochondrial Biogenesis and Provides an Endogenous Neuroprotective Mechanism Against Seizure-Induced Neuronal Cell Death in the Hippocampus Following Status Epilepticus

Status epilepticus may decrease mitochondrial biogenesis, resulting in neuronal cell death occurring in the hippocampus. Sirtuin 1 (SIRT1) functionally interacts with peroxisome proliferator-activated receptors and γ coactivator 1α (PGC-1α), which play a crucial role in the regulation of mitochondri...

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Bibliographic Details
Main Authors: Yao-Chung Chuang, Shang-Der Chen, Shuo-Bin Jou, Tsu-Kung Lin, Shu-Fang Chen, Nai-Ching Chen, Chung-Yao Hsu
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:International Journal of Molecular Sciences
Subjects:
SIRT1
PGC-1α
mitochondrial biogenesis
status epilepticus
hippocampus
Online Access:https://www.mdpi.com/1422-0067/20/14/3588

Internet

https://www.mdpi.com/1422-0067/20/14/3588

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