Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination

Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination

Following demyelination injury, neural stem cells (NSCs) in the subventricular zone switch to an activated state. Here, the authors show that a transient shift from non-canonical to canonical Wnt signaling is necessary for activation of quiescent NSCs to achieve tissue homeostasis and brain repair.

Bibliographic Details
Main Authors: Manideep Chavali, Michael Klingener, Alexandros G. Kokkosis, Yury Garkun, Sylwia Felong, Arianna Maffei, Adan Aguirre
Format: Article
Language:English
Published: Nature Publishing Group 2018-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02440-0

Internet

https://doi.org/10.1038/s41467-017-02440-0

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