Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination

Following demyelination injury, neural stem cells (NSCs) in the subventricular zone switch to an activated state. Here, the authors show that a transient shift from non-canonical to canonical Wnt signaling is necessary for activation of quiescent NSCs to achieve tissue homeostasis and brain repair.

Bibliographic Details
Main Authors: Manideep Chavali, Michael Klingener, Alexandros G. Kokkosis, Yury Garkun, Sylwia Felong, Arianna Maffei, Adan Aguirre
Format: Article
Language:English
Published: Nature Publishing Group 2018-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02440-0
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spelling doaj-9bb5de1bd6e4464ba36ebf8b3edcb8052021-05-11T09:43:56ZengNature Publishing GroupNature Communications2041-17232018-01-019111710.1038/s41467-017-02440-0Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelinationManideep Chavali0Michael Klingener1Alexandros G. Kokkosis2Yury Garkun3Sylwia Felong4Arianna Maffei5Adan Aguirre6Department of Pharmacological Sciences, Stony Brook UniversityDepartment of Pharmacological Sciences, Stony Brook UniversityDepartment of Pharmacological Sciences, Stony Brook UniversityDepartment of Neurobiology and Behavior, Stony Brook UniversityDepartment of Pharmacological Sciences, Stony Brook UniversityDepartment of Neurobiology and Behavior, Stony Brook UniversityDepartment of Pharmacological Sciences, Stony Brook UniversityFollowing demyelination injury, neural stem cells (NSCs) in the subventricular zone switch to an activated state. Here, the authors show that a transient shift from non-canonical to canonical Wnt signaling is necessary for activation of quiescent NSCs to achieve tissue homeostasis and brain repair.https://doi.org/10.1038/s41467-017-02440-0
collection DOAJ
language English
format Article
sources DOAJ
author Manideep Chavali
Michael Klingener
Alexandros G. Kokkosis
Yury Garkun
Sylwia Felong
Arianna Maffei
Adan Aguirre
spellingShingle Manideep Chavali
Michael Klingener
Alexandros G. Kokkosis
Yury Garkun
Sylwia Felong
Arianna Maffei
Adan Aguirre
Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination
Nature Communications
author_facet Manideep Chavali
Michael Klingener
Alexandros G. Kokkosis
Yury Garkun
Sylwia Felong
Arianna Maffei
Adan Aguirre
author_sort Manideep Chavali
title Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination
title_short Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination
title_full Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination
title_fullStr Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination
title_full_unstemmed Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination
title_sort non-canonical wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-01-01
description Following demyelination injury, neural stem cells (NSCs) in the subventricular zone switch to an activated state. Here, the authors show that a transient shift from non-canonical to canonical Wnt signaling is necessary for activation of quiescent NSCs to achieve tissue homeostasis and brain repair.
url https://doi.org/10.1038/s41467-017-02440-0
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