Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination
Following demyelination injury, neural stem cells (NSCs) in the subventricular zone switch to an activated state. Here, the authors show that a transient shift from non-canonical to canonical Wnt signaling is necessary for activation of quiescent NSCs to achieve tissue homeostasis and brain repair.
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2018-01-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-017-02440-0 |
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doaj-9bb5de1bd6e4464ba36ebf8b3edcb8052021-05-11T09:43:56ZengNature Publishing GroupNature Communications2041-17232018-01-019111710.1038/s41467-017-02440-0Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelinationManideep Chavali0Michael Klingener1Alexandros G. Kokkosis2Yury Garkun3Sylwia Felong4Arianna Maffei5Adan Aguirre6Department of Pharmacological Sciences, Stony Brook UniversityDepartment of Pharmacological Sciences, Stony Brook UniversityDepartment of Pharmacological Sciences, Stony Brook UniversityDepartment of Neurobiology and Behavior, Stony Brook UniversityDepartment of Pharmacological Sciences, Stony Brook UniversityDepartment of Neurobiology and Behavior, Stony Brook UniversityDepartment of Pharmacological Sciences, Stony Brook UniversityFollowing demyelination injury, neural stem cells (NSCs) in the subventricular zone switch to an activated state. Here, the authors show that a transient shift from non-canonical to canonical Wnt signaling is necessary for activation of quiescent NSCs to achieve tissue homeostasis and brain repair.https://doi.org/10.1038/s41467-017-02440-0 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Manideep Chavali Michael Klingener Alexandros G. Kokkosis Yury Garkun Sylwia Felong Arianna Maffei Adan Aguirre |
spellingShingle |
Manideep Chavali Michael Klingener Alexandros G. Kokkosis Yury Garkun Sylwia Felong Arianna Maffei Adan Aguirre Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination Nature Communications |
author_facet |
Manideep Chavali Michael Klingener Alexandros G. Kokkosis Yury Garkun Sylwia Felong Arianna Maffei Adan Aguirre |
author_sort |
Manideep Chavali |
title |
Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination |
title_short |
Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination |
title_full |
Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination |
title_fullStr |
Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination |
title_full_unstemmed |
Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination |
title_sort |
non-canonical wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2018-01-01 |
description |
Following demyelination injury, neural stem cells (NSCs) in the subventricular zone switch to an activated state. Here, the authors show that a transient shift from non-canonical to canonical Wnt signaling is necessary for activation of quiescent NSCs to achieve tissue homeostasis and brain repair. |
url |
https://doi.org/10.1038/s41467-017-02440-0 |
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