Chromosome rearrangements shape the diversification of secondary metabolism in the cyclosporin producing fungus Tolypocladium inflatum

Chromosome rearrangements shape the diversification of secondary metabolism in the cyclosporin producing fungus Tolypocladium inflatum

Abstract Background Genes involved in production of secondary metabolites (SMs) in fungi are exceptionally diverse. Even strains of the same species may exhibit differences in metabolite production, a finding that has important implications for drug discovery. Unlike in other eukaryotes, genes produ...

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Bibliographic Details
Main Authors: Rodrigo A. Olarte, Jon Menke, Ying Zhang, Shawn Sullivan, Jason C. Slot, Yinyin Huang, Jonathan P. Badalamenti, Alisha C. Quandt, Joseph W. Spatafora, Kathryn E. Bushley
Format: Article
Language:English
Published: BMC 2019-02-01
Series:BMC Genomics
Subjects:
Fungi
Secondary metabolism
Genome evolution
Structural variation
Chromosome rearrangement
Hi-C
Online Access:http://link.springer.com/article/10.1186/s12864-018-5399-x

Internet

http://link.springer.com/article/10.1186/s12864-018-5399-x

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