miR-155-5p modulates malignant behaviors of hepatocellular carcinoma by directly targeting CTHRC1 and indirectly regulating GSK-3β-involved Wnt/β-catenin signaling

miR-155-5p modulates malignant behaviors of hepatocellular carcinoma by directly targeting CTHRC1 and indirectly regulating GSK-3β-involved Wnt/β-catenin signaling

Abstract Background Hepatocellular carcinoma (HCC) remains one of the most lethal cancers. MicroRNA-155 (miR-155) and collagen triple helix repeat containing 1 (CTHRC1) were found to be involved in hepatocarcinogenesis, but their detailed functions in HCC are unclear. Here, we aimed to investigate t...

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Bibliographic Details
Main Authors: Gang Chen, Dongdong Wang, Xiongqi Zhao, Jun Cao, Yingpeng Zhao, Fan Wang, Jianhua Bai, Ding Luo, Li Li
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Cancer Cell International
Subjects:
Hepatocellular carcinoma (HCC)
Malignant behaviors
microRNA-155-5p (miR-155-5p)
Collagen triple helix repeat containing 1 (CTHRC1)
GSK-3β-involved Wnt/β-catenin signaling
Online Access:http://link.springer.com/article/10.1186/s12935-017-0469-8

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http://link.springer.com/article/10.1186/s12935-017-0469-8

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