A 3D-QSAR Study on the Antitrypanosomal and Cytotoxic Activities of Steroid Alkaloids by Comparative Molecular Field Analysis

A 3D-QSAR Study on the Antitrypanosomal and Cytotoxic Activities of Steroid Alkaloids by Comparative Molecular Field Analysis

As part of our research for new leads against human African trypanosomiasis (HAT), we report on a 3D-QSAR study for antitrypanosomal activity and cytotoxicity of aminosteroid-type alkaloids recently isolated from the African medicinal plant Holarrhena africana A. DC. (Apocynaceae), some of which are...

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Bibliographic Details
Main Authors: Charles Okeke Nnadi, Julia Barbara Althaus, Ngozi Justina Nwodo, Thomas Jürgen Schmidt
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:Molecules
Subjects:
aminosteroid
aminocycloartane
alkaloid
3D-QSAR
CoMFA
antitrypanosomal activity
cytotoxicity
Online Access:http://www.mdpi.com/1420-3049/23/5/1113

Internet

http://www.mdpi.com/1420-3049/23/5/1113

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