Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined <it>Apc</it><sup><it>Min </it></sup>and <it>KRAS</it><sup><it>V</it>12 </sup>mutations
<p>Abstract</p> <p>Background</p> <p>Both mutational inactivation of the adenomatous polyposis coli (<it>APC</it>) tumor suppressor gene and activation of the <it>KRAS </it>oncogene are implicated in the pathogenesis of colorectal cancer. Mice ha...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2010-03-01
|
Series: | Molecular Cancer |
Online Access: | http://www.molecular-cancer.com/content/9/1/63 |