Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined <it>Apc</it><sup><it>Min </it></sup>and <it>KRAS</it><sup><it>V</it>12 </sup>mutations

Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined <it>Apc</it><sup><it>Min </it></sup>and <it>KRAS</it><sup><it>V</it>12 </sup>mutations

<p>Abstract</p> <p>Background</p> <p>Both mutational inactivation of the adenomatous polyposis coli (<it>APC</it>) tumor suppressor gene and activation of the <it>KRAS </it>oncogene are implicated in the pathogenesis of colorectal cancer. Mice ha...

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Bibliographic Details
Main Authors: Robine Sylvie, Patel Nilesh V, McConnell Beth B, Ghaleb Amr M, Nandan Mandayam O, Yang Vincent W
Format: Article
Language:English
Published: BMC 2010-03-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/9/1/63

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