A novel SOD mimic with a redox-modulating mn (II) complex, ML1 attenuates high glucose-induced abnormalities in intracellular Ca2+ transients and prevents cardiac cell death through restoration of mitochondrial function

A novel SOD mimic with a redox-modulating mn (II) complex, ML1 attenuates high glucose-induced abnormalities in intracellular Ca2+ transients and prevents cardiac cell death through restoration of mitochondrial function

A key contributor to the pathophysiology of diabetic cardiomyopathy, mitochondrial superoxide can be adequately countered by Mn-superoxide dismutase, which constitutes the first line of defense against mitochondrial oxidative stress. Our group has recently synthesized low molecular weight SOD mimics...

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Bibliographic Details
Main Authors: Vasundhara Kain, Mithila A. Sawant, Aparajita Dasgupta, Gaurav Jaiswal, Alok Vyas, Subhash Padhye, Sandhya L. Sitasawad
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Biochemistry and Biophysics Reports
Subjects:
Mn-Superoxide dismutase
Mitochondrial superoxide
Diabetic cardiomyopathy
Hyperglycemia
ARVM
Cardiomyocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580816000042

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http://www.sciencedirect.com/science/article/pii/S2405580816000042

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