Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin

Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin

Objective: The mechanistic target of rapamycin complex 1 (mTORC1) is dynamically regulated by fasting and feeding cycles in the liver to promote protein and lipid synthesis while suppressing autophagy. However, beyond these functions, the metabolic response of the liver to feeding and insulin signal...

Full description

Bibliographic Details
Main Authors: Vanessa Byles, Yann Cormerais, Krystle Kalafut, Victor Barrera, James E. Hughes Hallett, Shannan Ho Sui, John M. Asara, Christopher M. Adams, Gerta Hoxhaj, Issam Ben-Sahra, Brendan D. Manning
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Molecular Metabolism
Subjects:
mTORC1
ATF4
Liver
Feeding
Insulin
Methionine metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821001563

Internet

http://www.sciencedirect.com/science/article/pii/S2212877821001563

Similar Items