Bradykinin B2 Receptor Contributes to Inflammatory Responses in Human Endothelial Cells by the Transactivation of the Fibroblast Growth Factor Receptor FGFR-1

Bradykinin B2 Receptor Contributes to Inflammatory Responses in Human Endothelial Cells by the Transactivation of the Fibroblast Growth Factor Receptor FGFR-1

Elevated levels of bradykinin (BK) and fibroblast growth factor-2 (FGF-2) have been implicated in the pathogenesis of inflammatory and angiogenic disorders. In angiogenesis, both stimuli induce a pro-inflammatory signature in endothelial cells, activating an autocrine/paracrine amplification loop th...

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Bibliographic Details
Main Authors: Erika Terzuoli, Federico Corti, Ginevra Nannelli, Antonio Giachetti, Sandra Donnini, Marina Ziche
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:International Journal of Molecular Sciences
Subjects:
bradykinin
B2R antagonist
endothelial cells
FGFR-1
Online Access:http://www.mdpi.com/1422-0067/19/9/2638

Internet

http://www.mdpi.com/1422-0067/19/9/2638

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