Blocks in Tricarboxylic Acid Cycle of Salmonella enterica Cause Global Perturbation of Carbon Storage, Motility, and Host-Pathogen Interaction

Blocks in Tricarboxylic Acid Cycle of Salmonella enterica Cause Global Perturbation of Carbon Storage, Motility, and Host-Pathogen Interaction

We performed perturbation analyses of the tricarboxylic acid cycle of the gastrointestinal pathogen Salmonella enterica serovar Typhimurium. The defect of fumarase activity led to accumulation of fumarate but also resulted in a global alteration of carbon fluxes, leading to increased storage of glyc...

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Bibliographic Details
Main Authors: Janina Noster, Nicole Hansmeier, Marcus Persicke, Tzu-Chiao Chao, Rainer Kurre, Jasmin Popp, Viktoria Liss, Tatjana Reuter, Michael Hensel
Format: Article
Language:English
Published: American Society for Microbiology 2019-12-01
Series:mSphere
Subjects:
tca cycle
glycogen metabolism
chemotaxis
phagocytosis
Online Access:https://doi.org/10.1128/mSphere.00796-19

Internet

https://doi.org/10.1128/mSphere.00796-19

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