Histone variants H2A.Z and H3.3 coordinately regulate PRC2-dependent H3K27me3 deposition and gene expression regulation in mES cells

Histone variants H2A.Z and H3.3 coordinately regulate PRC2-dependent H3K27me3 deposition and gene expression regulation in mES cells

Abstract Background The hierarchical organization of eukaryotic chromatin plays a central role in gene regulation, by controlling the extent to which the transcription machinery can access DNA. The histone variants H3.3 and H2A.Z have recently been identified as key regulatory players in this proces...

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Main Authors: Yan Wang, Haizhen Long, Juan Yu, Liping Dong, Michel Wassef, Baowen Zhuo, Xia Li, Jicheng Zhao, Min Wang, Cuifang Liu, Zengqi Wen, Luyuan Chang, Ping Chen, Qian-fei Wang, Xueqing Xu, Raphael Margueron, Guohong Li
Format: Article
Language:English
Published: BMC 2018-09-01
Series:BMC Biology
Online Access:http://link.springer.com/article/10.1186/s12915-018-0568-6

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http://link.springer.com/article/10.1186/s12915-018-0568-6

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