Promoter Hypermethylation of Tumor-Suppressor Genes <i>p16<sup>INK4a</sup>, RASSF1A, TIMP3</i>, and <i>PCQAP/MED15</i> in Salivary DNA as a Quadruple Biomarker Panel for Early Detection of Oral and Oropharyngeal Cancers

Promoter Hypermethylation of Tumor-Suppressor Genes <i>p16<sup>INK4a</sup>, RASSF1A, TIMP3</i>, and <i>PCQAP/MED15</i> in Salivary DNA as a Quadruple Biomarker Panel for Early Detection of Oral and Oropharyngeal Cancers

Silencing of tumor-suppressor genes (TSGs) by DNA promoter hypermethylation is an early event in carcinogenesis; hence, TSGs may serve as early tumor biomarkers. We determined the promoter methylation levels of <i>p16<sup>INK4a</sup></i>, <i>RASSF1A</i>, <i>...

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Bibliographic Details
Main Authors: Chamikara Liyanage, Asanga Wathupola, Sanjayan Muraleetharan, Kanthi Perera, Chamindie Punyadeera, Preethi Udagama
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Biomolecules
Subjects:
oral cancer
oropharyngeal cancer
tumor-suppressor genes
promoter hypermethylation
Online Access:https://www.mdpi.com/2218-273X/9/4/148

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https://www.mdpi.com/2218-273X/9/4/148

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