Synthesis and In Vitro Cytotoxicity of the 4-(Halogenoanilino)-6-bromoquinazolines and Their 6-(4-Fluorophenyl) Substituted Derivatives as Potential Inhibitors of Epidermal Growth Factor Receptor Tyrosine Kinase

Synthesis and In Vitro Cytotoxicity of the 4-(Halogenoanilino)-6-bromoquinazolines and Their 6-(4-Fluorophenyl) Substituted Derivatives as Potential Inhibitors of Epidermal Growth Factor Receptor Tyrosine Kinase

Series of the 2-unsubstituted and 2-(4-chlorophenyl)–substituted 4-anilino-6-bromoquinazolines and their 6-(4-fluorophenyl)–substituted derivatives were evaluated for in vitro cytotoxicity against MCF-7 and HeLa cells. The 2-unsubstituted 4-anilino-6-bromoquinazolines lacked activity, whereas most o...

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Bibliographic Details
Main Authors: Malose Jack Mphahlele, Hugues K. Paumo, Yee Siew Choong
Format: Article
Language:English
Published: MDPI AG 2017-11-01
Series:Pharmaceuticals
Subjects:
6-bromo-4-chloroquinazolines
amination
Suzuki–Miyaura cross-coupling
cytotoxicity
EGFR-TK
molecular docking
Online Access:https://www.mdpi.com/1424-8247/10/4/87

Internet

https://www.mdpi.com/1424-8247/10/4/87

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