Insights Into the Somatic Mutation Burden of Hepatoblastomas From Brazilian Patients

Insights Into the Somatic Mutation Burden of Hepatoblastomas From Brazilian Patients

Hepatoblastoma is a very rare embryonal liver cancer supposed to arise from the impairment of hepatocyte differentiation during embryogenesis. In this study, we investigated by exome sequencing the burden of somatic mutations in a cohort of 10 hepatoblastomas, including a congenital case. Our data d...

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Bibliographic Details
Main Authors: Talita Ferreira Marques Aguiar, Maria Prates Rivas, Silvia Costa, Mariana Maschietto, Tatiane Rodrigues, Juliana Sobral de Barros, Anne Caroline Barbosa, Renan Valieris, Gustavo R. Fernandes, Debora R. Bertola, Monica Cypriano, Silvia Regina Caminada de Toledo, Angela Major, Israel Tojal, Maria Lúcia de Pinho Apezzato, Dirce Maria Carraro, Carla Rosenberg, Cecilia Maria Lima da Costa, Isabela W. Cunha, Stephen Frederick Sarabia, Dolores-López Terrada, Ana Cristina Victorino Krepischi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Oncology
Subjects:
hepatoblastoma
CTNNB1
CX3CL1
CEP164
chemokine signaling
cytokine receptor interaction
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00556/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00556/full

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