LIN28A expression reduces sickling of cultured human erythrocytes.

LIN28A expression reduces sickling of cultured human erythrocytes.

Induction of fetal hemoglobin (HbF) has therapeutic importance for patients with sickle cell disease (SCD) and the beta-thalassemias. It was recently reported that increased expression of LIN28 proteins or decreased expression of its target let-7 miRNAs enhances HbF levels in cultured primary human...

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Bibliographic Details
Main Authors: Jaira F de Vasconcellos, Ross M Fasano, Y Terry Lee, Megha Kaushal, Colleen Byrnes, Emily R Meier, Molly Anderson, Antoinette Rabel, Raul Braylan, David F Stroncek, Jeffery L Miller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4154803?pdf=render

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http://europepmc.org/articles/PMC4154803?pdf=render

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