Modulating CRISPR gene drive activity through nucleocytoplasmic localization of Cas9 in S. cerevisiae

Modulating CRISPR gene drive activity through nucleocytoplasmic localization of Cas9 in S. cerevisiae

Abstract Background The bacterial CRISPR/Cas genome editing system has provided a major breakthrough in molecular biology. One use of this technology is within a nuclease-based gene drive. This type of system can install a genetic element within a population at unnatural rates. Combatting of vector-...

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Bibliographic Details
Main Authors: Megan E. Goeckel, Erianna M. Basgall, Isabel C. Lewis, Samantha C. Goetting, Yao Yan, Megan Halloran, Gregory C. Finnigan
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Fungal Biology and Biotechnology
Subjects:
CRISPR
Cas9
Gene drive
Biotechnology
Nucleocytoplasmic trafficking
Yeast
Online Access:http://link.springer.com/article/10.1186/s40694-019-0065-x

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http://link.springer.com/article/10.1186/s40694-019-0065-x

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