Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescence

Functional CRISPR screen identifies AP1-associated enhancer regulating FOXF1 to modulate oncogene-induced senescence

Abstract Background Functional characterization of non-coding elements in the human genome is a major genomic challenge and the maturation of genome-editing technologies is revolutionizing our ability to achieve this task. Oncogene-induced senescence, a cellular state of irreversible proliferation a...

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Bibliographic Details
Main Authors: Ruiqi Han, Li Li, Alejandro Piñeiro Ugalde, Arieh Tal, Zohar Manber, Eric Pinto Barbera, Veronica Della Chiara, Ran Elkon, Reuven Agami
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Genome Biology
Subjects:
CRISPR
Functional screen
Enhancers
Oncogene-induced senescence
Gene regulation
AP1
Online Access:http://link.springer.com/article/10.1186/s13059-018-1494-1

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http://link.springer.com/article/10.1186/s13059-018-1494-1

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