A rat model of organophosphate-induced status epilepticus and the beneficial effects of EP2 receptor inhibition

A rat model of organophosphate-induced status epilepticus and the beneficial effects of EP2 receptor inhibition

This review describes an adult rat model of status epilepticus (SE) induced by diisopropyl fluorophosphate (DFP), and the beneficial outcomes of transient inhibition of the prostaglandin-E2 receptor EP2 with a small molecule antagonist, delayed by 2–4 h after SE onset. Administration of six doses of...

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Bibliographic Details
Main Authors: Asheebo Rojas, Thota Ganesh, Wenyi Wang, Jennifer Wang, Raymond Dingledine
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Neurobiology of Disease
Subjects:
Diisopropyl fluorophosphate
EP2
Albumin
Acetylcholinesterase
Neurodegeneration
Status epilepticus
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119300427

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http://www.sciencedirect.com/science/article/pii/S0969996119300427

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