Chromatography-tandem MASS spectrometry (HPLC-MS/MS) for the detection of valproic acid and its metabolites in blood plasma

Chromatography-tandem MASS spectrometry (HPLC-MS/MS) for the detection of valproic acid and its metabolites in blood plasma

Aim: to adapt the HPLC-MS/MS technique to determining valproic acid and its metabolites in blood plasma for drug therapy monitoring.Materials and Methods: The chromatographic assay was run using an Agilent 1260 Infinity II chromatograph with a Phenomenex synergi Fusion analytical column 4 μm-C18 2×5...

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Bibliographic Details
Main Authors: A. S. Malygin, N. S. Popov, M. A. Demidova, M. N. Kudrayshova
Format: Article
Language:Russian
Published: IRBIS LLC 2018-08-01
Series:Эпилепсия и пароксизмальные состояния
Subjects:
hplc-ms/ms
antiepileptic drugs
valproic acid
metabolites
drug therapy monitoring.
Online Access:https://www.epilepsia.su/jour/article/view/407

Internet

https://www.epilepsia.su/jour/article/view/407

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