Melatonin Enhances Mitophagy by Upregulating Expression of Heat Shock 70 kDa Protein 1L in Human Mesenchymal Stem Cells under Oxidative Stress

Melatonin Enhances Mitophagy by Upregulating Expression of Heat Shock 70 kDa Protein 1L in Human Mesenchymal Stem Cells under Oxidative Stress

Human mesenchymal stem cells (hMSCs) are a potent source of cell-based regenerative therapeutics used to treat patients with ischemic disease. However, disease-induced oxidative stress disrupts mitochondrial homeostasis in transplanted hMSCs, resulting in hMSC apoptosis and reducing their efficacy p...

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Bibliographic Details
Main Authors: Yeo Min Yoon, Hyung Joo Kim, Jun Hee Lee, Sang Hun Lee
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
oxidative stress
mesenchymal stem cells
mitochondria
melatonin
mitophagy
HSPA1L
parkin
Online Access:https://www.mdpi.com/1422-0067/20/18/4545

Internet

https://www.mdpi.com/1422-0067/20/18/4545

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