A One-Pot Three-Component Double-Click Method for Synthesis of [67Cu]-Labeled Biomolecular Radiotherapeutics

A One-Pot Three-Component Double-Click Method for Synthesis of [67Cu]-Labeled Biomolecular Radiotherapeutics

Abstract A one-pot three-component double-click process for preparing tumor-targeting agents for cancer radiotherapy is described here. By utilizing DOTA (or NOTA) containing tetrazines and the TCO-substituted aldehyde, the two click reactions, the tetrazine ligation (an inverse electron-demand Diel...

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Bibliographic Details
Main Authors: Katsumasa Fujiki, Shinya Yano, Takeshi Ito, Yuki Kumagai, Yoshinori Murakami, Osamu Kamigaito, Hiromitsu Haba, Katsunori Tanaka
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-02123-2

Internet

https://doi.org/10.1038/s41598-017-02123-2

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