Impact of Pre-Analytical Variables on Cancer Targeted Gene Sequencing Efficiency.

Tumor specimens are often preserved as formalin-fixed paraffin-embedded (FFPE) tissue blocks, the most common clinical source for DNA sequencing. Herein, we evaluated the effect of pre-sequencing parameters to guide proper sample selection for targeted gene sequencing. Data from 113 FFPE lung tumor...

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Bibliographic Details
Main Authors: Luiz H Araujo, Cynthia Timmers, Konstantin Shilo, Weiqiang Zhao, Jianying Zhang, Lianbo Yu, Thanemozhi G Natarajan, Clinton J Miller, Ayse Selen Yilmaz, Tom Liu, Joseph Amann, José Roberto Lapa E Silva, Carlos Gil Ferreira, David P Carbone
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4659597?pdf=render