15-Lipoxygenase-1 Production is Lost in Pancreatic Cancer and Overexpression of the Gene Inhibits Tumor Cell Growth

15-Lipoxygenase-1 Production is Lost in Pancreatic Cancer and Overexpression of the Gene Inhibits Tumor Cell Growth

Pancreatic cancer patients have an abysmal prognosis because of late diagnosis and lack of therapeutic options. Pancreatic intraepithelial neoplasias (PaniNs), the precursor lesions, are a potential target for chemoprevention. Targeting eicosanoid pathways is an obvious choice because 5-lipoxygenas...

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Bibliographic Details
Main Authors: René Hennig, Timo Kehl, Seema Noor, Xian-Zhong Ding, Sambasiva M. Rao, Frank Bergmann, Gerhard Fürstenberger, Markus W. Büchler, Helmut Friess, Peter Krieg, Thomas E. Adrian
Format: Article
Language:English
Published: Elsevier 2007-11-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Pancreatic cancer
15-lipoxygenase-1
pancreatic intraepithelial neoplasia
tubular complexes
chronic pancreatitis
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558607800200

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http://www.sciencedirect.com/science/article/pii/S1476558607800200

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