Expression of tyrosine hydroxylase isoforms and phosphorylation at serine 40 in the human nigrostriatal system in Parkinson's disease

Expression of tyrosine hydroxylase isoforms and phosphorylation at serine 40 in the human nigrostriatal system in Parkinson's disease

Tyrosine hydroxylase is the key enzyme controlling the synthesis of the catecholamines including dopamine. The breakdown of dopamine into toxic compounds has been suggested to have a key role in the degeneration of the dopaminergic neurons in Parkinson's disease. Humans are unique in containing...

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Bibliographic Details
Main Authors: Jacqueline Shehadeh, Kay L. Double, Karen E. Murphy, Larisa Bobrovskaya, Stefanie Reyes, Peter R. Dunkley, Glenda M. Halliday, Phillip W. Dickson
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Neurobiology of Disease
Subjects:
Tyrosine hydroxylase
Human
Isoform
Parkinson's disease
Phosphorylation
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996119301925

Internet

http://www.sciencedirect.com/science/article/pii/S0969996119301925

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