Chaperones, Membrane Trafficking and Signal Transduction Proteins Regulate Zaire Ebola Virus trVLPs and Interact With trVLP Elements

Chaperones, Membrane Trafficking and Signal Transduction Proteins Regulate Zaire Ebola Virus trVLPs and Interact With trVLP Elements

Ebolavirus (EBOV) life cycle involves interactions with numerous host factors, but it remains poorly understood, as does pathogenesis. Herein, we synthesized 65 siRNAs targeting host genes mostly connected with aspects of the negative-sense RNA virus life cycle (including viral entry, uncoating, fus...

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Bibliographic Details
Main Authors: Dong-Shan Yu, Tian-Hao Weng, Chen-Yu Hu, Zhi-Gang Wu, Yan-Hua Li, Lin-Fang Cheng, Nan-Ping Wu, Lan-Juan Li, Hang-Ping Yao
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Microbiology
Subjects:
Ebola virus life cycle
trVLPs
RNAi screening
glycoprotein
protein 40
immunoprecipitation
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.02724/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.02724/full

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