A genome-wide survey of mutations in the Jurkat cell line

A genome-wide survey of mutations in the Jurkat cell line

Abstract Background The Jurkat cell line has an extensive history as a model of T cell signaling. But at the turn of the 21st century, some expression irregularities were observed, raising doubts about how closely the cell line paralleled normal human T cells. While numerous expression deficiencies...

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Bibliographic Details
Main Authors: Louis Gioia, Azeem Siddique, Steven R. Head, Daniel R. Salomon, Andrew I. Su
Format: Article
Language:English
Published: BMC 2018-05-01
Series:BMC Genomics
Subjects:
Jurkat
Whole-genome sequencing
Cancer
T-cell
Genome stability
T-cell receptor
Online Access:http://link.springer.com/article/10.1186/s12864-018-4718-6

Internet

http://link.springer.com/article/10.1186/s12864-018-4718-6

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