Fast detection of de novo copy number variants from SNP arrays for case-parent trios

Fast detection of de novo copy number variants from SNP arrays for case-parent trios

<p>Abstract</p> <p>Background</p> <p>In studies of case-parent trios, we define copy number variants (CNVs) in the offspring that differ from the parental copy numbers as de novo and of interest for their potential functional role in disease. Among the leading array-bas...

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Bibliographic Details
Main Authors: Scharpf Robert B, Beaty Terri H, Schwender Holger, Younkin Samuel G, Scott Alan F, Ruczinski Ingo
Format: Article
Language:English
Published: BMC 2012-12-01
Series:BMC Bioinformatics
Subjects:
Trios
Oral cleft
Copy number variants
de novo
High-throughput arrays
Segmentation
batch effects
Genomic waves
Online Access:http://www.biomedcentral.com/1471-2105/13/330

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http://www.biomedcentral.com/1471-2105/13/330

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