The HIV-1 Reverse Transcriptase A62V Mutation Influences Replication Fidelity and Viral Fitness in the Context of Multi-Drug-Resistant Mutations

The HIV-1 Reverse Transcriptase A62V Mutation Influences Replication Fidelity and Viral Fitness in the Context of Multi-Drug-Resistant Mutations

Emergence of human immunodeficiency virus type 1 (HIV-1) drug resistance arises from mutation fixation in the viral genome during antiretroviral therapy. Primary mutations directly confer antiviral drug resistance, while secondary mutations arise that do not confer drug resistance. The A62V amino ac...

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Bibliographic Details
Main Authors: José O. Maldonado, Louis M. Mansky
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Viruses
Subjects:
lentivirus
immunodeficiency virus
viral fitness
viral mutagenesis
compensatory mutation
Online Access:http://www.mdpi.com/1999-4915/10/7/376

Internet

http://www.mdpi.com/1999-4915/10/7/376

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