NIAM-deficient mice are predisposed to the development of proliferative lesions including B-cell lymphomas.

NIAM-deficient mice are predisposed to the development of proliferative lesions including B-cell lymphomas.

Nuclear Interactor of ARF and Mdm2 (NIAM, gene designation Tbrg1) is a largely unstudied inhibitor of cell proliferation that helps maintain chromosomal stability. It is a novel activator of the ARF-Mdm2-Tip60-p53 tumor suppressor pathway as well as other undefined pathways important for genome main...

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Bibliographic Details
Main Authors: Sara M Reed, Jussara Hagen, Viviane P Muniz, Timothy R Rosean, Nick Borcherding, Sebastian Sciegienka, J Adam Goeken, Paul W Naumann, Weizhou Zhang, Van S Tompkins, Siegfried Janz, David K Meyerholz, Dawn E Quelle
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4231569?pdf=render

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http://europepmc.org/articles/PMC4231569?pdf=render

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