Down-Regulation of MHC Class I Expression in Human Keratinocytes Using Viral Vectors Containing <i>US11</i> Gene of Human Cytomegalovirus and Cultivation on Bovine Collagen-Elastin Matrix (Matriderm<sup>®</sup>): Potential Approach for an Immune-Privileged Skin Substitute

Down-Regulation of MHC Class I Expression in Human Keratinocytes Using Viral Vectors Containing <i>US11</i> Gene of Human Cytomegalovirus and Cultivation on Bovine Collagen-Elastin Matrix (Matriderm<sup>®</sup>): Potential Approach for an Immune-Privileged Skin Substitute

Skin transplantation, especially in burn patients, is still challenging because surgeons are faced with limited disposability of autologous donor side material. The in vitro culture of keratinocytes has become an important reconstructive option. However, only non-immunogenic allogenic keratinocytes...

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Bibliographic Details
Main Authors: Frederik Schlottmann, Sarah Strauss, Kevin Hake, Peter M. Vogt, Vesna Bucan
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:International Journal of Molecular Sciences
Subjects:
MHC I receptor
US11 gene
primary keratinocytes
skin graft
Matriderm<sup>®</sup>
Online Access:https://www.mdpi.com/1422-0067/20/9/2056

Internet

https://www.mdpi.com/1422-0067/20/9/2056

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