O-GlcNacylation Links TxNIP to Inflammasome Activation in Pancreatic β Cells

O-GlcNacylation Links TxNIP to Inflammasome Activation in Pancreatic β Cells

Thioredoxin interacting protein (TxNIP), which strongly responds to glucose, has emerged as a central mediator of glucotoxicity in pancreatic β cells. TxNIP is a scaffold protein interacting with target proteins to inhibit or stimulate their activity. Recent studies reported that high glucose stimul...

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Bibliographic Details
Main Authors: Gaelle Filhoulaud, Fadila Benhamed, Patrick Pagesy, Caroline Bonner, Yann Fardini, Anissa Ilias, Jamileh Movassat, Anne-Françoise Burnol, Sandra Guilmeau, Julie Kerr-Conte, François Pattou, Tarik Issad, Catherine Postic
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Endocrinology
Subjects:
O-GlcNAcylation
TXNIP (thioredoxin-interacting protein)
pancreatic beta cells
hyperglycemia
inflammasome
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00291/full

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https://www.frontiersin.org/article/10.3389/fendo.2019.00291/full

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