Co-evolution networks of HIV/HCV are modular with direct association to structure and function.

Mutational correlation patterns found in population-level sequence data for the Human Immunodeficiency Virus (HIV) and the Hepatitis C Virus (HCV) have been demonstrated to be informative of viral fitness. Such patterns can be seen as footprints of the intrinsic functional constraints placed on vira...

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Bibliographic Details
Main Authors: Ahmed Abdul Quadeer, David Morales-Jimenez, Matthew R McKay
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-09-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1006409