Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection.

Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection.

Progress in the fight against the HIV/AIDS epidemic is hindered by our failure to elucidate the precise reasons for the onset of immunodeficiency in HIV-1 infection. Increasing evidence suggests that elevated immune activation is associated with poor outcome in HIV-1 pathogenesis. However, the basis...

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Bibliographic Details
Main Authors: Laura Papagno, Celsa A Spina, Arnaud Marchant, Mariolina Salio, Nathalie Rufer, Susan Little, Tao Dong, Gillian Chesney, Anele Waters, Philippa Easterbrook, P Rod Dunbar, Dawn Shepherd, Vincenzo Cerundolo, Vincent Emery, Paul Griffiths, Christopher Conlon, Andrew J McMichael, Douglas D Richman, Sarah L Rowland-Jones, Victor Appay
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2004-02-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.0020020

Internet

https://doi.org/10.1371/journal.pbio.0020020

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