Levetiracetam resistance: Synaptic signatures & corresponding promoter SNPs in epileptic hippocampi

Levetiracetam resistance: Synaptic signatures & corresponding promoter SNPs in epileptic hippocampi

Pharmacoresistance to antiepileptic drugs (AEDs) is a major clinical problem in patients with mesial temporal lobe epilepsy (mTLE). Levetiracetam (LEV) represents a unique type of AED as its high-affinity binding site, the synaptic vesicle protein SV2A, is a component of the presynaptic release mach...

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Bibliographic Details
Main Authors: Tanja Grimminger, Katharina Pernhorst, Rainer Surges, Pitt Niehusmann, Lutz Priebe, Marec von Lehe, Per Hoffmann, Sven Cichon, Susanne Schoch, Albert J. Becker
Format: Article
Language:English
Published: Elsevier 2013-12-01
Series:Neurobiology of Disease
Subjects:
A priori non-responders
Luciferase
Promoter variants
PIGP
Presynapse
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113002362

Internet

http://www.sciencedirect.com/science/article/pii/S0969996113002362

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