Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition

Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition

Abstract Background Triggering receptor expressed on myeloid cell-2 (TREM2) is a lipid and lipoprotein binding receptor expressed by cells of myeloid origin. Homozygous TREM2 mutations cause early onset progressive presenile dementia while heterozygous, point mutations triple the risk of Alzheimer’s...

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Bibliographic Details
Main Authors: Brittani R. Price, Tiffany L. Sudduth, Erica M. Weekman, Sherika Johnson, Danielle Hawthorne, Abigail Woolums, Donna M. Wilcock
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Journal of Neuroinflammation
Subjects:
TREM2
Trem2
Alzheimer’s disease
Beta-amyloid
Immunotherapy
Neuroinflammation
Online Access:http://link.springer.com/article/10.1186/s12974-020-01915-0

Internet

http://link.springer.com/article/10.1186/s12974-020-01915-0

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